Inhaled Antibiotics for Cysyic Fibrosis

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Permalink Reply by Zahara Zawawi on March 13, 2009 at 6:51am

I have never used this medication but I came across it in a study featured on medscape the articale is called:

"Aerosolized Ceftazidime for Prevention of Ventilator-Associated Pneumonia and Drug Effects on the Proinflammatory Response in Critically Ill Trauma Patients"
G. Christopher Wood, Pharm.D., Bradley A. Boucher, Pharm.D., FCCP, Martin A. Croce, M.D., Scott D. Hanes, Pharm.D., Vanessa L. Herring, B.S., Timothy C. Fabian, M.D.

It was posted on 10/04/2002


this is the link to the study but you need to have an account with medsscape which is easy to create

http://www.medscape.com/viewarticle/441275_5

I copied the parts that mention the medication here:
"Study-drug administration was performed by respiratory therapists according to recommendations for optimizing aerosolized drug delivery in patients receiving mechanical ventilation.[32, 33] Specifically, each dose was administered by means of a disposable jet nebulizer with a median mass aerosol diameter of 1-5 µm (Airlife Misty-Neb; Baxter Healthcare, Deerfield, IL) filled with 4 ml of ceftazidime solution (62.5 mg/ml) or normal saline for injection. The nebulizer was connected to the inspiratory loop of the ventilator tubing 30 cm from the endotracheal tube. During administration, the ventilator (Puritan Bennett 7200 series; Nellcor Puritan Bennett, Pleasanton, CA) was set to nebulize only during inspiration, using a high nebulizer airflow rate (7.5 L/min). Ventilator humidification was turned off during administration. Study-drug doses were prepared in syringes every 48 hours in the hospital pharmacy with use of an aseptic technique in a laminar flow hood. All ceftazidime doses were prepared in normal saline for injection (final pH 7.0)."

"Patients randomly were assigned to receive either ceftazidime 250 mg (Fortaz; GlaxoWellcome, Research Triangle Park, NC) or placebo (normal saline for injection) every 12 hours for 7 days by nebulization."

Just keep in mind that the dosage used in the study was a prophylactic dose as I understand.

I hope it helps.

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Permalink Reply by Steve Kutchman on March 13, 2009 at 4:37pm

Thank you, that will be helpful.

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